Microsoft Research Debuts Quine, a Multimodal World Model of Biology

Microsoft Research on September 29, 2026, introduced Quine, a research effort built around a multimodal world model of biology and an interactive harness that links the model to orchestration and reasoning models, scientific tools, the research literature, the wet lab, and the teams of scientists using them.

With the announcement, Microsoft opened applications for the first Quine Fellows cohort and reported that, working with researchers at the Broad Institute of MIT and Harvard, it has used the system to rank compounds predicted to produce therapeutic shifts in tumor cell state, with several top-ranked candidates validated across multiple wet-lab assays.

The announcement is authored by Nicolo Fusi, VP and distinguished scientist, and Jonathan M. Carlson, vice president.

A World Model Built Across Biological Scales

Microsoft defines the world model it is pursuing as one that represents the state of a biological system, forecasts how that state would change…