Mayo Clinic AI detects pancreatic cancer up to three years before diagnosis in landmark validation study – Mayo Clinic News Network

Mayo Clinic AI detects pancreatic cancer up to three years before diagnosis in landmark validation study – Mayo Clinic News Network

By Susan Murphy
Publication Date: 2026-04-29 10:00:00

ROCHESTER, Minn. – An artificial intelligence (AI) model developed by the Mayo Clinic may help specialists detect pancreatic cancer during routine abdominal CT scans up to three years before clinical diagnosis. It identifies subtle signs of disease before tumors become visible, when curative treatment may still be possible. The findings, published in Gut, represent a milestone in Mayo Clinic’s multi-year research effort to enable earlier detection of one of the deadliest cancers.

The study validates this next-generation AI model using data and workflows that reflect clinical practice, including multi-institutional CT scans, imaging systems, and protocols.

Researchers used the AI ​​model to analyze nearly 2,000 CT scans, including scans from patients later diagnosed with pancreatic cancer – all initially interpreted as normal. The…