Scientists use AI to design life-like enzymes from scratch

Scientists use AI to design life-like enzymes from scratch

An enzyme structure designed using a combination of machine-learning tools. Credit: Sam Pellock

Researchers have used artificial intelligence (AI) to design brand-new enzymes that can go through multi-step reactions, a key feature of natural enzymes. The structures they made accelerated a four-step chemical reaction pivotal to many biological and industrial processes, including plastic recycling.

“This is a milestone in enzyme engineering,” says Huimin Zhao, a synthetic biologist at the…

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https://www.nature.com/articles/d41586-025-00488-3