By Daragh Thomas
Publication Date: 2026-03-09 15:01:00
“Pharma Bro” Martin Shkreli has published a detailed bull case for photonic computing Thursday , sayinghe is now actively working at Q/C Technologies Inc., the micro-cap firm he first invested in last December.
Shkreli’s Substack essay, titled “Photonic Computing: The Final AI Hardware Frontier,” lays out a simple thesis: GPUs from Nvidia Corp. spend roughly 99% of their time doing one thing, matrix multiplication.
Trillions of dollars in market value exist to make that single calculation faster and cheaper.
Photonic computing uses light instead of electrical signals to do the same math.
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Shkreli argues light can handle these operations in near-linear time versus cubic time for GPUs. On large matrices, that difference could be enormous.
Shkreli was named a strategic advisor to QCLS in December. His partner Chelsea Voss, a member of technical staff at OpenAI, joined the board in January.
If Shkreli is right, some large prediction market contracts in crypto would need to reprice.
Polymarket gives Nvidia a 61% chance of ending 2026 as the world’s largest company by market cap, and the AI bubble burst contract sits at 19% by year-end , with one trigger being NVDA falling 50% from its all-time high.
Both markets assume GPU dominance holds.
Shkreli is betting it doesn’t. If photonic computing scales, GPU pricing power could compress.
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